IODx

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CHECKPOINT MATE™
TOTAL SOLUTION FOR IMMUNO-ONCOLOGY DRUGS

BACKGROUND

The immune system plays an important role in controlling and eradicating cancer. In the setting of malignancy, multiple mechanisms of immune suppression may exist that prevent effective antitumor immunity. Tumor can adapt and circumvent the natural defense mechanisms (immune checkpoint systems) . Tumors can evade adaptive immunity and disrupt 下cell checkpoint pathways (CTLA-4 , PO-1 , PO-L 1, and 1001). Immuno-Oncology drugs utilizes the body's own immune system to fight cancer and aim to reverse the inhibition of adaptive immunity leading to active stimulation of a patient's immune systems

OUR STRATEGY

Immuno-Oncology drugs are focusing on the complex interplay between dendritic cell , T cell, and tumor cel l. Furthermore, the drugs kill tumor cells by triggering a series of interaction between cell to cell as well molecule to molecule. In this regard , our multi-gene expression-based approach should be very useful for the development of effective COx test for immuno-oncology drugs.

Focused on the biological characteristics of tumor cells in the setting of immuno surveillance, we have investigated the gene expression profiles of tumor antigens, major histocompatibility complex molecules, and key regulators in apoptosis pathway which are selected through bioinformatics and meta analysis

RComplex multi-step communication between immune cells and tumor cells

SELECTED DATA

T-test and KM analysis shows that some of the biomarkers are significantly different in expression levels between tumor and surrounding non-tumor tissues and prognostic difference

SELECTED DATA

Subgroup analysis shows that some of th e biomarkers have prognostic significance only in patient subgroup with certain c li n i c。 pathological characteristics. Based on these results, combination of biomarker expression and clinicopathological parameters could help select patient inc lusion criteria in clinical t rials of immuno-oncology drugs